Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke

被引：66

作者：

Kaplan, Robert C. ^{[1
]}

Smith, Nicholas L. ^{[2
,6
,7
]}

Zucker, Stanley ^{[8
]}

Heckbert, Susan R. ^{[2
,7
]}

Rice, Kenneth ^{[3
]}

Psaty, Bruce M. ^{[2
,4
,5
,7
]}

机构：

[1] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] Univ Washington, Dept Hlth Serv, Seattle, WA USA

[6] Seattle Epidemiol Res & Informat Ctr, Off Res & Dev, Dept Vet Affairs, Seattle, WA USA

[7] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA 98101 USA

[8] Vet Affairs Med Ctr, Northport, NY USA

来源：

ATHEROSCLEROSIS | 2008年 / 201卷 / 01期

关键词：

Myocardial infarction; Stroke; Genetics;

D O I：

10.1016/j.atherosclerosis.2008.01.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke. Methods: A case-control study was conducted among members of Group Health (GH), a large-integrated health care delivery system. Case subjects with incident non-fatal myocardial infarction (n = 854), ischemic stroke (it = 367), and hemorrhagic stroke (it = 66) were identified and validated. A matched control group was selected from among GH members without myocardial infarction or stroke (it = 2696). Haplotype-tagging sets of single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. Results: MMP3 haplotype 2 was associated with reduced risk of myocardial infarction (adjusted odds ratio (OR) per copy = 0.80, 95% confidence interval 0.66. 0.98) and increased risk of hemorrhagic stroke (OR = 1.69, 95% confidence interval 1.05, 2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for myocardial infarction but did not achieve statistical significance (OR = 0.85, 95% confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke. Conclusions: MMP3 haplotype may predict both cardiac events and stroke. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 137

页数：8

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