Purpose of review Molecular diagnosis has become an indispensable tool in allergy. In suspected idiopathic anaphylaxis, it is mandatory to extend the diagnostic search to its limits. The current review evaluates how molecular diagnosis allows to identify a number of difficult to prove potential culprits. Recent findings Depending on different geographical areas, it has been shown that the number of anaphylaxis labelled as idiopathic may decrease by the use of molecular diagnosis. The most relevant allergens identified are alpha-gal, omega-5-gliadin,Anisakis, lipid transfer proteins and oleosins. The role of cofactors has been shown to be relevant in a high proportion of cases. Mast cell disorders should always be ruled out. There is a need to provide further molecular diagnostic tests for use in clinical practice to identify sensitization to allergens not well represented in current commercial assays.
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Alvarez-Twose, I.
;
Gonzalez-de-Olano, D.
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Hosp Fuenlabrada, Serv Alergol, Madrid, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Gonzalez-de-Olano, D.
;
Sanchez-Munoz, L.
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机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Sanchez-Munoz, L.
;
Matito, A.
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Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Matito, A.
;
Jara-Acevedo, M.
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h-index: 0
机构:
Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Jara-Acevedo, M.
;
Teodosio, C.
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Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Teodosio, C.
;
Garcia-Montero, A.
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Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Garcia-Montero, A.
;
Morgado, J. M.
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Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Morgado, J. M.
;
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Orfao, A.
;
Escribano, L.
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Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Alvarez-Twose, I.
;
Gonzalez-de-Olano, D.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Fuenlabrada, Serv Alergol, Madrid, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Gonzalez-de-Olano, D.
;
Sanchez-Munoz, L.
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h-index: 0
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Sanchez-Munoz, L.
;
Matito, A.
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h-index: 0
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Matito, A.
;
Jara-Acevedo, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Jara-Acevedo, M.
;
Teodosio, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Teodosio, C.
;
Garcia-Montero, A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Serv Gen Citometria, Ctr Invest Canc IBMCC USAL CSIC, E-37008 Salamanca, Spain
Univ Salamanca, Dept Med, E-37008 Salamanca, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Garcia-Montero, A.
;
Morgado, J. M.
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h-index: 0
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain
Morgado, J. M.
;
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h-index:
机构:
Orfao, A.
;
Escribano, L.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, SpainHosp Virgen del Valle, Inst Estudios Mastocitosis Castilla La Mancha CLM, ES-45071 Toledo, Spain