Relationship between expression of plasminogen activator system and metastatic ability in human cancers

被引：0
作者：
NoguchiTakino, M
Endo, Y
Yonemura, Y
Sasaki, T
机构：
[1] KANAZAWA UNIV, CANC RES INST, DEPT EXPTL THERAPEUT, SCH MED, KANAZAWA, ISHIKAWA 920, JAPAN
[2] KANAZAWA UNIV, SCH MED, DEPT SURG 2, KANAZAWA, ISHIKAWA 920, JAPAN
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1996年 / 8卷 / 01期
关键词：
urokinase-type plasminogen activator; plasminogen activator inhibitor; reverse transcription-PCR; chick embryo; gastric cancer; metastasis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The gene expressions of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PR), and plasminogen activator inhibitor (PAI)-1 and -2 in human tumor cell lines and human gastric cancer tissues were analyzed using the reverse transcription (RT)-PCR. The expression patterns were compared with experimental metastatic ability in chick embryo or clinicopathological findings. The results indicate that the function of u-PA binding to u-PR and the diminished expression of PAI-2 are significantly involved in the process of cancer metastasis and PAI-2 may be more effective in regulating u-PA activity than PAI-1.
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页码：97 / 105
页数：9
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