Bioactive peptides derived from human milk proteins - mechanisms of action

被引：165

作者：

Wada, Yasuaki ^{[1
,2
]}

Loennerdal, Bo ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[2] Morinaga Milk Ind Co Ltd, Nutr Sci Inst, Higashihara, Zama 2528583, Japan

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2014年 / 25卷 / 05期

关键词：

Human milk; Bioactive peptide; Gastrointestinal digestion; Casein; a-Lactalbumin; Lactoferrin; I-CONVERTING-ENZYME; ALPHA-LACTALBUMIN SUPPLEMENTATION; KAPPA-CASEIN GLYCOMACROPEPTIDE; GROWTH-PROMOTING ACTIVITY; HUMAN INTESTINAL-CELL; BETA-CASOMORPHIN; OPIOID-PEPTIDES; BOVINE GLYCOMACROPEPTIDE; CALCIUM-ABSORPTION; INHIBITORY PEPTIDES;

D O I：

10.1016/j.jnutbio.2013.10.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human milk contains a multitude of bioactive proteins with very diverse functions, which are beneficial for the rapidly growing neonate. The large variety of bioactivities is accomplished by the combination of bioactive proteins per se and gastrointestinal release of bioactive peptides derived from them. The bioactivities exerted by these peptides include enhancement of mineral absorption, immunomodulation, opioid, antihypertensive and antimicrobial activities. Notably, several of the activities are not attributed to the parental proteins, but exclusively to released bioactive peptides. This article reviews studies on bioactive peptides derived from major human milk proteins, such as caseins, alpha-lactalbumin and lactoferrin, during gastrointestinal digestion. Studies of bovine milk counterparts are also cited as a comparison. (C) 2014 Published by Elsevier Inc.

引用

页码：503 / 514

页数：12

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