Topology of mammalian developmental enhancers and their regulatory landscapes

被引：374
作者：
de Laat, Wouter [1 ,2 ]
Duboule, Denis [3 ,4 ]
机构：
[1] Hubrecht Inst KNAW, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands
[3] Ecole Polytech Fed Lausanne, Sch Life Sci, CH-1015 Lausanne, Switzerland
[4] Univ Geneva, Dept Genet & Evolut, CH-1211 Geneva, Switzerland
来源：
NATURE | 2013年 / 502卷 / 7472期
基金：
新加坡国家研究基金会;
关键词：
GLOBIN LOCUS REQUIRES; GENE-EXPRESSION; CONTROL REGION; SPATIAL-ORGANIZATION; HYPERSENSITIVE SITES; STRUCTURAL VARIATION; TRANSCRIPTION; ELEMENTS; GENOME; LIMB;
D O I：
10.1038/nature12753
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend on the precise expression of genes in space and time. The orchestration of transcription relies mostly on surrounding control sequences such as enhancers, millions of which form complex regulatory landscapes in the non-coding genome. Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.
引用
收藏
页码：499 / 506
页数：8
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