Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives

被引：128
|
作者：
Mazzotti, Anthony R. [1 ]
Campbell, Michael G. [1 ]
Tang, Pingping [1 ]
Murphy, Jennifer M. [1 ]
Ritter, Tobias [1 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 38期
基金：
美国国家科学基金会;
关键词：
COPPER-MEDIATED FLUORINATION; C-H FLUORINATION; REDUCTIVE ELIMINATION; ELECTROPHILIC FLUORINATION; PD(III); DEOXYFLUORINATION; CONVERSION; MECHANISM;
D O I：
10.1021/ja405919z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.
引用
收藏
页码：14012 / 14015
页数：4
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