Automated versus manual segmentation of brain region volumes in former football players

被引：34

作者：

Guenette, Jeffrey P. ^{[1
,2
]}

Stern, Robert A. ^{[3
,4
,5
,6
]}

Tripodis, Yorghos ^{[3
,7
]}

Chua, Alicia S. ^{[7
]}

Schultz, Vivian ^{[1
,8
]}

Sydnor, Valerie J. ^{[1
]}

Somes, Nathaniel ^{[1
]}

Karmacharya, Sarina ^{[1
]}

Lepage, Christian ^{[1
]}

Wrobel, Pawel ^{[8
]}

Alosco, Michael L. ^{[3
]}

Martin, Brett M. ^{[9
]}

Chaisson, Christine E. ^{[3
,9
]}

Coleman, Michael J. ^{[1
]}

Lin, Alexander P. ^{[1
,2
,10
]}

Pasternak, Ofer ^{[1
,2
]}

Makris, Nikos ^{[1
,2
,11
]}

Shenton, Martha E. ^{[1
,2
,12
]}

Koerte, Inga K. ^{[1
,8
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA USA

[3] Boston Univ, BU Alzheimers Dis & CTE Ctr, Boston, MA 02215 USA

[4] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[5] Boston Univ, Sch Med, Dept Neurosurg, Boston, MA 02118 USA

[6] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

[7] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[8] Ludwig Maximilians Univ Munchen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany

[9] Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA

[10] Harvard Med Sch, Brigham & Womens Hosp, Ctr Clin Spect, Boston, MA USA

[11] Massachusetts Gen Hosp, Ctr Neural Syst Invest, Boston, MA 02114 USA

[12] VA Boston Healthcare Syst, Brockton Div, Brockton, MA USA

来源：

NEUROIMAGE-CLINICAL | 2018年 / 18卷

基金：

加拿大健康研究院;

关键词：

Magnetic resonance imaging; Neuroimaging; Head trauma; Traumatic brain injury; Chronic traumatic encephalopathy; CHRONIC TRAUMATIC ENCEPHALOPATHY; VENTRICULAR ENLARGEMENT; HIPPOCAMPUS SEGMENTATION; ALZHEIMERS-DISEASE; AMYGDALA VOLUMES; METAANALYSIS; FREESURFER; ATROPHY; SCHIZOPHRENIA; RELIABILITY;

D O I：

10.1016/j.nicl.2018.03.026

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Objectives: To determine whether or not automated FreeSurfer segmentation of brain regions considered important in repetitive head trauma can be analyzed accurately without manual correction. Materials and methods: 3 T MR neuroimaging was performed with automated FreeSurfer segmentation and manual correction of 11 brain regions in former National Football League (NFL) players with neurobehavioral symptoms and in control subjects. Automated segmentation and manually-corrected volumes were compared using an intraclass correlation coefficient (ICC). Linear mixed effects regression models were also used to estimate between-group mean volume comparisons and to correlate former NFL player brain volumes with neurobehavioral factors. Results: Eighty-six former NFL players (55.2 +/- 8.0 years) and 22 control subjects (57.0 +/- 6.6 years) were evaluated. ICC was highly correlated between automated and manually-corrected corpus callosum volumes (0.911), lateral ventricular volumes (right 0.980, left 0.967), and amygdala-hippocampal complex volumes (right 0.713, left 0.731), but less correlated when amygdalae (right -0.170, left -0.090) and hippocampi (right 0.539, left 0.637) volumes were separately delineated and also less correlated for cingulate gyri volumes (right 0.639, left 0.351). Statistically significant differences between former NFL player and controls were identified in 8 of 11 regions with manual correction but in only 4 of 11 regions without such correction. Within NFL players, manually corrected brain volumes were significantly associated with 3 neurobehavioral factors, but a different set of 3 brain regions and neurobehavioral factor correlations was observed for brain region volumes segmented without manual correction. Conclusions: Automated FreeSurfer segmentation of the corpus callosum, lateral ventricles, and amygdala-hippocampus complex may be appropriate for analysis without manual correction. However, FreeSurfer segmentation of the amygdala, hippocampus, and cingulate gyrus need further manual correction prior to performing group comparisons and correlations with neurobehavioral measures.

引用

页码：888 / 896

页数：9

共 57 条

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