Recent advances in the development and evaluation of molecular diagnostics for Ebola virus disease

被引：13

作者：

Tembo, John ^{[1
]}

Simulundu, Edgar ^{[2
]}

Changula, Katendi ^{[2
]}

Handley, Dale ^{[3
]}

Gilbert, Matthew ^{[3
]}

Chilufya, Moses ^{[1
]}

Asogun, Danny ^{[4
]}

Ansumana, Rashid ^{[5
]}

Kapata, Nathan ^{[6
]}

Ntoumi, Francine ^{[7
]}

Ippolito, Giuseppe ^{[8
]}

Zumla, Alimuddin ^{[9
,10
]}

Bates, Matthew

机构：

[1] Univ Teaching Hosp, HerpeZ, Lusaka, Zambia

[2] Univ Zambia, Sch Vet Med, Dept Dis Control, Lusaka, Zambia

[3] Univ Lincoln, Sch Life Sci, Lincoln, England

[4] Irrua Univ Teaching Hosp, Lassa Fever Res Inst, Irrua, Nigeria

[5] Univ Njala, Mercy Hosp, Bo, Sierra Leone

[6] Zambia Natl Publ Hlth Inst, Lusaka, Zambia

[7] Fdn Congolaise Rech Med, Brazzaville, Rep Congo

[8] IRCCS, Lazzaro Spallanzani, Natl Inst Infect Dis, Rome, Italy

[9] UCL, Ctr Clin Microbiol, Div Infect & Immun, London, England

[10] UCL Hosp Natl Hlth Serv Fdn Trust, Natl Inst Hlth & Res, Biomed Res Ctr, London, England

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2019年 / 19卷 / 04期

关键词：

Ebola; diagnostics; EVD; outbreaks; preparedness; ANTIGEN RAPID TEST; POINT-OF-CARE; VIRAL HEMORRHAGIC-FEVER; REAL-TIME; WEST-AFRICA; TEST KIT; LABORATORY RESPONSE; SEXUAL TRANSMISSION; ZAIRE-EBOLAVIRUS; FIELD VALIDATION;

D O I：

10.1080/14737159.2019.1595592

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: The 2014-16 outbreak of ebola virus disease (EVD) in West Africa resulted in 11,308 deaths. During the outbreak only 60% of patients were laboratory confirmed and global health authorities have identified the need for accurate and readily deployable molecular diagnostics as an important component of the ideal response to future outbreaks, to quickly identify and isolate patients.Areas covered: Currently PCR-based techniques and rapid diagnostic tests (RDTs) that detect antigens specific to EVD infections dominate the diagnostic landscape, but recent advances in biosensor technologies have led to novel approaches for the development of EVD diagnostics. This review summarises the literature and available performance data of currently available molecular diagnostics for ebolavirus, identifies knowledge gaps and maps out future priorities for research in this field.Expert opinion: While there are now a plethora of diagnostic tests for EVD at various stages of development, there is an acute need for studies to compare their clinical performance, but the sporadic nature of EVD outbreaks makes this extremely challenging, demanding pragmatic new modalities of research funding and ethical/institutional approval, to enable responsive research in outbreak settings. Retrospective head-to-head diagnostic comparisons could also be implemented using biobanked specimens, providing this can be done safely.

引用

页码：325 / 340

页数：16

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