Digoxin-Macrolide drug interaction

被引:27
作者
Bizjak, ED
Mauro, VF
机构
[1] UNIV TOLEDO, COLL PHARM, TOLEDO, OH 43606 USA
[2] MED COLL OHIO, DEPT MED, TOLEDO, OH 43699 USA
关键词
D O I
10.1177/106002809703100918
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Macrolide antibiotics appear to be able to enhance the oral bioavailability of digoxin by altering the gastrointestinal flora that metabolize digoxin to less active dihydro metabolites, thus leading to increased serum digoxin concentrations and possible digoxin toxicity in select patients stabilized on digoxin therapy. This interaction may be of clinical importance in up to 10% of the population. Currently, the orally administered erythromycin, clarithromycin, and roxithromycin have been implicated. Although realistically this interaction may be encountered rarely, when it does occur, it can be of clinical significance.
引用
收藏
页码:1077 / 1079
页数:3
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