Safety of Mesenchymal Stem Cells for Clinical Application

被引：173

作者：

Wang, Youwei ^{[1
,2
,3
]}

Han, Zhi-bo ^{[1
,2
,3
]}

Song, Yong-ping ^{[4
]}

Han, Zhong Chao ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Hosp Blood Dis, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

[4] Zhengzhou Univ, Affiliated Tumor Hosp Zhengzhou, Dept Hematol, Zhengzhou 450052, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2012年 / 2012卷

关键词：

SPONTANEOUS MALIGNANT-TRANSFORMATION; CROSS-CONTAMINATION; STROMAL CELLS; COPY NUMBER; CULTURE; REVEALS; LINES;

D O I：

10.1155/2012/652034

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.

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