The Role of ARID1A in Endometrial Cancer and the Molecular Pathways Associated With Pathogenesis and Cancer Progression

被引：28
作者：
Toumpeki, Chrisavgi [1 ]
Liberis, Anastasios [2 ]
Tsirkas, Ioannis [1 ]
Tsirka, Theodora [3 ]
Kalagasidou, Sofia [4 ]
Inagamova, Lola [1 ]
Anthoulaki, Xanthoula [1 ]
Tsatsaris, Georgios [1 ]
Kontomanolis, Emmanuel N. [1 ]
机构：
[1] Democritus Univ Thrace, Dept Obstet & Gynecol, Alexandroupolis, Greece
[2] Hippokrateion Hosp, Dept Obstet & Gynecol 2, Thessaloniki, Greece
[3] Univ Thrace, Dept Mol Biol & Genet, Alexandroupolis, Greece
[4] Bodosakio Gen Hosp Ptolemaida, Dept Obstet & Gynecol, Ptolemaida, Greece
来源：
IN VIVO | 2019年 / 33卷 / 03期
关键词：
ARID1A; endometrial cancer; molecular pathways; review; TUMOR-SUPPRESSOR; CLINICOPATHOLOGICAL SIGNIFICANCE; SOMATIC MUTATIONS; CELL CARCINOMA; EXPRESSION; COMPLEXES; GENES; ADENOCARCINOMA; LANDSCAPE; COMPONENT;
D O I：
10.21873/invivo.11524
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
AT-rich interaction domain 1A gene (ARID1A) encodes for a subunit of the switch/sucrose non fermentable (SWI/SNF) complex, a chromatin remodeling complex, and it has been implicated in the pathogenesis of various cancer types. In this review, we discuss how ARID1A is linked to endometrial cancer and what molecular pathways are affected by mutation or inhibition of ARID1A. We also discuss the potential use of ARID1A not only as a prognostic biomarker, but also as a target for therapeutic interventions.
引用
收藏
页码：659 / 667
页数：9
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