A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

被引：3

作者：

Wan, Wen ^{[1
]}

Ma, Guobin ^{[1
]}

Gao, Wei ^{[1
]}

Wang, Jing ^{[1
]}

Li, Lei ^{[1
]}

Rao, Shangqin ^{[1
]}

Zheng, Chunfang ^{[1
]}

Jiang, Haizhen ^{[1
]}

Deng, Hongmei ^{[2
]}

Hao, Jian ^{[1
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Lab Microstruct, Shanghai, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Inst Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 38期

基金：

中国国家自然科学基金;

关键词：

SPONGE CLATHRIA-LISSOSCLERA; STEREOCHEMICAL COURSE; CATALYTIC REDUCTION; GAMMA-LACTONES; PROGESTOGEN; STEROIDS; DERIVATIVES; HYDROLYSIS;

D O I：

10.1039/c3ob41211c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile strategy for the preparation of two isomeric drospirenones 13 and 16 possessing a 14 beta-hydrogen was developed, using 3 beta-hydroxyandrost-5-en-17-one as the starting material. The total synthetic route involves eight steps, giving 2% overall yield. The structures of the main compounds 11, 13, 14 and 16 were determined by single crystal XRD analysis.

引用

页码：6597 / 6603

页数：7

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