A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response

被引：31

作者：

Campanella, C. ^{[2
]}

Gammazza, A. Marino ^{[2
]}

Mularoni, L. ^{[1
]}

Cappello, F. ^{[2
]}

Zummo, G. ^{[2
]}

Di Felice, V. ^{[2
]}

机构：

[1] Fundacio Inst Municipal Invest Med, Res Unit Biomed Informat, Barcelona, Spain

[2] Univ Palermo, Dipartimento Med Sperimentale, Sez Anat Umana E Luna, I-90127 Palermo, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2009年 / 36卷 / 01期

关键词：

HEAT-SHOCK-PROTEIN; TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS; MOLECULAR CHAPERONES; IN-VITRO; HEAT-SHOCK-PROTEIN-60; EXPRESSION; ANTIGEN; CARCINOGENESIS; PATHOGENESIS;

D O I：

10.1111/j.1744-313X.2008.00819.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.

引用

页码：73 / 78

页数：6

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