Ailing bones and failing kidneys: a case of chronic cadmium toxicity

被引:44
作者
Chakraborty, Sutirtha [1 ]
Dutta, Arup R. [2 ]
Sural, Saubhik [3 ]
Gupta, Debkishore [4 ]
Sen, Susruta [5 ]
机构
[1] Peerless Hosp & BK Roy Res Ctr, Dept Biochem, Kolkata 700094, W Bengal, India
[2] Fortis Hosp & Kidney Inst, Dept Nephrol, Kolkata, India
[3] Peerless Hosp & BK Roy Res Ctr, Dept Nephrol, Kolkata 700094, W Bengal, India
[4] Peerless Hosp & BK Roy Res Ctr, Dept Microbiol, Kolkata 700094, W Bengal, India
[5] Calcutta Med Res Inst, Dept Biochem, Kolkata, India
关键词
Disease; bone disorders; toxicology; FANCONI-SYNDROME; EXPOSURE; LEAD;
D O I
10.1177/0004563213481207
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Heavy metal toxicity is often caused by occupational exposure. Chronic cadmium toxicity is a significant health concern among workers engaged in zinc smelting, battery production and silver jewellery industries, particularly in developing countries. We report the case of a 48-year-old man who presented with severe osteoporosis, impaired renal function and acquired Fanconi syndrome. He was finally diagnosed with chronic cadmium toxicity resulting from long-term occupational exposure. Cadmium has a long biological half-life and there is no effective treatment for people who are exposed to it. Therefore, an early diagnosis and prevention of further exposure are important.
引用
收藏
页码:492 / 495
页数:4
相关论文
共 13 条
[1]  
Bernard AM, 1997, AM J IND MED, V31, P116
[2]   Cadmium induces apoptosis in the human osteoblast-like cell line Saos-2 [J].
Coonse, K. G. ;
Coonts, A. J. ;
Morrison, E. V. ;
Heggland, S. J. .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2007, 70 (07) :575-581
[3]  
Gonick HC, 2008, INDIAN J MED RES, V128, P335
[4]   Acquired Fanconi syndrome with osteomalacia secondary to monoclonal gammopathy of undetermined significance [J].
Hashimoto, Toru ;
Arakawa, Kimika ;
Ohta, Yuko ;
Suehiro, Takaichi ;
Uesugi, Noriko ;
Nakayama, Masaru ;
Tsuchihashi, Takuya .
INTERNAL MEDICINE, 2007, 46 (05) :241-245
[5]   Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies [J].
Horiguchi, Hyogo ;
Aoshima, Keiko ;
Oguma, Etsuko ;
Sasaki, Satoshi ;
Miyamoto, Kayoko ;
Hosoi, Yoko ;
Katoh, Terutaka ;
Kayama, Fujio .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2010, 83 (08) :953-970
[6]  
Jarup Lars, 1998, Scandinavian Journal of Work Environment and Health, V24, P1
[7]   Metallothionein protection of cadmium toxicity [J].
Klaassen, Curtis D. ;
Liu, Jie ;
Diwan, Bhalchandra A. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 238 (03) :215-220
[8]   Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication:: Cadmium and lead distribution and analysis in different mice organs [J].
Massadeh, A. M. ;
Al-Safi, S. A. ;
Momani, I. F. ;
Alomary, A. A. ;
Jaradat, Q. M. ;
AlKofahi, A. S. .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2007, 120 (1-3) :227-234
[9]   Cadherins and NCAM as potential targets in metal toxicity [J].
Prozialeck, WC ;
Grunwald, GB ;
Dey, PM ;
Reuhl, KR ;
Parrish, AR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 182 (03) :255-265
[10]  
RAGHAVAN SRV, 1980, MINER ELECTROL METAB, V3, P36