Methadone

被引：23

作者：

Chhabra, Shalini ^{[2
,3
]}

Bull, Janet ^{[1
]}

机构：

[1] Four Seasons Hosp & Palliat Care, Hendersonville, NC USA

[2] E Tennessee State Univ, Dept Med, Johnson City, TN 37684 USA

[3] James H Quillen Vet Affairs Med Ctr Mt Home, Home Based Primary Care, Johnson City, TN USA

来源：

AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE | 2008年 / 25卷 / 02期

关键词：

pharmacodynamics; bioavailability; indications; equianalgesic dosing; methadone toxicity;

D O I：

10.1177/1049909107312597

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing. It is critical when using the drug to monitor for signs and symptoms of toxicity so that overdosing or toxicity can be identified in a timely manner. This review discusses these important topics so that methadone can be used safely and effectively.

引用

页码：146 / 150

页数：5

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