The Use of Mathematical Modelling for Improving the Tissue Engineering of Organs and Stem Cell Therapy

被引：6

作者：

Lemon, Greg ^{[1
]}

Sjoqvist, Sebastian ^{[1
]}

Lim, Mei Ling ^{[1
]}

Feliu, Neus ^{[1
]}

Firsova, Alexandra B. ^{[1
]}

Amin, Risul ^{[1
]}

Gustafsson, Ylva ^{[1
]}

Stuewer, Annika ^{[1
]}

Haag, Johannes ^{[1
]}

Jungebluth, Philipp ^{[1
]}

Macchiarini, Paolo ^{[2
]}

机构：

[1] Karolinska Inst, Adv Ctr Translat Regenerat Med ACTREM, Dept Clin Sci Intervent & Technol CLINTEC, Huddinge, Sweden

[2] Kazan Fed Univ, Lab Bioengn & Regenerat Med BioReM, Kazan, Russia

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2016年 / 11卷 / 08期

关键词：

Regenerative medicine; tissue engineering; stem cell therapy; stem cells; mathematical modelling; computational modelling; IN-VIVO; GROWTH; MULTISCALE; SCAFFOLDS; PROLIFERATION; BIOREACTORS; TRANSPORT; DELIVERY; MSCS; DIFFERENTIATION;

D O I：

10.2174/1574888X10666151001115942

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Regenerative medicine is a multidisciplinary field where continued progress relies on the incorporation of a diverse set of technologies from a wide range of disciplines within medicine, science and engineering. This review describes how one such technique, mathematical modelling, can be utilised to improve the tissue engineering of organs and stem cell therapy. Several case studies, taken from research carried out by our group, ACTREM, demonstrate the utility of mechanistic mathematical models to help aid the design and optimisation of protocols in regenerative medicine.

引用

页码：666 / 675

页数：10

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