Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2-Bipyridine

被引:37
作者
Scaeteanu, Gina Vasile [1 ]
Chifiriuc, Mariana Carmen [2 ,3 ]
Bleotu, Coralia [4 ]
Kamerzan, Crina [2 ,3 ,5 ]
Marutescu, Luminita [2 ,3 ]
Daniliuc, Constantin G. [6 ]
Maxim, Catalin [7 ]
Calu, Larisa [7 ]
Olar, Rodica [7 ]
Badea, Mihaela [7 ]
机构
[1] Univ Agron Sci & Vet Med, Dept Soil Sci, 59 Marasti Str,Sect 1, Bucharest 011464, Romania
[2] Univ Bucharest, Dept Microbiol, Fac Biol, 1-3 Aleea Portocalelor Str, Bucharest 60101, Romania
[3] Univ Bucharest ICUB, Res Inst, Life Environm & Earth Sci Div, Spl Independentei 91-95, Bucharest 010271, Romania
[4] Stefan S Nicolau Inst Virol, 285 Mihai Bravu Ave, Bucharest 030304, Romania
[5] SC Sanimed Int Impex SRL, Sos Bucuresti Magurele 70F,Sect 5, Bucharest 051434, Romania
[6] Westfal Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany
[7] Univ Bucharest, Dept Inorgan Chem, Fac Chem, 90-92 Panduri Str, Bucharest 050663, Romania
关键词
2; 2-bipyridine complexes; acrylato ligand; trinuclear complex; antifungal activity; CRYSTAL-STRUCTURE; THERMAL-BEHAVIOR; MANGANESE(II) COMPLEXES; COORDINATION POLYMERS; COPPER(II) COMPLEXES; MAGNETIC-PROPERTIES; II COMPLEXES; BEARING; AMINE; STABILITY;
D O I
10.3390/molecules23010157
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn-3(2,2-bipy)(2)(C3H3O2)(6)] (1), meanwhile complexes with general formula [M(2,2-bipy)(C3H3O2)(2)(H2O)(x)].yH(2)O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2-bipy: 2,2-bipyridine; C3H3O2: acrylate anion) were shown to be mononuclear. The lowest minimum inhibitory concentration (MIC) of 128 g mL(-1) was recorded for all four tested complexes against Candida albicans, for complex (3) against Escherichia coli, and for complex (4) against Staphylocococcus aureus. Compounds (3) and (4) were also potent efflux pumps activity inhibitors (EPI), proving their potential for use in synergistic combinations with antibiotics. Complexes (1)-(4) revealed that they were not cytotoxic to HCT-8 cells. They also proved to interfere with the cellular cycle of tumour HCT-8 cells by increasing the number of cells found in the S and G2/M phases. Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents.
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页数:18
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