Challenges faced in the clinical application of artificial anal sphincters

被引：13
作者：
Wang, Ming-hui [1 ]
Zhou, Ying [1 ]
Zhao, Shuang [1 ,2 ]
Luo, Yun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Mech Engn, Inst Biomed Mfg & Life Qual Engn, State Key Lab Mech Syst & Vibrat, Shanghai 200240, Peoples R China
[2] Shanghai Dianji Univ, Sch Mech Engn, Shanghai 200240, Peoples R China
来源：
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2015年 / 16卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Fecal incontinence (FI); Artificial anal sphincter (AAS); Biomechanical compatibility; Smart materials; SEVERE FECAL INCONTINENCE; SHAPE-MEMORY ALLOYS; QUALITY-OF-LIFE; BOWEL SPHINCTER; SURGICAL THERAPIES; SINGLE INSTITUTION; IMPLANTATION; SYSTEM; PREVALENCE; PROSTHESIS;
D O I：
10.1631/jzus.B1400242
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fecal incontinence is an unresolved problem, which has a serious effect on patients, both physically and psychologically. For patients with severe symptoms, treatment with an artificial anal sphincter could be a potential option to restore continence. Currently, the Acticon Neosphincter is the only device certified by the US Food and Drug Administration. In this paper, the clinical safety and efficacy of the Acticon Neosphincter are evaluated and discussed. Furthermore, some other key studies on artificial anal sphincters are presented and summarized. In particular, this paper highlights that the crucial problem in this technology is to maintain long-term biomechanical compatibility between implants and surrounding tissues. Compatibility is affected by changes in both the morphology and mechanical properties of the tissues surrounding the implants. A new approach for enhancing the long-term biomechanical compatibility of implantable artificial sphincters is proposed based on the use of smart materials.
引用
收藏
页码：733 / 742
页数：10
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