Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

被引:647
|
作者
Astuti, Indwiani [1 ]
Ysrafil [1 ]
机构
[1] Univ Gadjah Mada, Dept Pharmacol & Therapy, Fac Med Publ Hlth & Nurses, Yogyakarta 55281, Indonesia
关键词
COVID-19; SARS-CoV-2; Pandemic; ACE2; Wuhan; RECEPTOR-BINDING DOMAIN; SPIKE PROTEIN; IMMUNE-RESPONSES; SARS-COV; NEUTRALIZING ANTIBODIES; COVID-19; VACCINE; INFECTION; ENZYMES; TARGET;
D O I
10.1016/j.dsx.2020.04.020
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aim: As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies. Method: We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review. Results: We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection. Conclusion: In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:407 / 412
页数:6
相关论文
共 50 条
  • [41] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion in hematology-oncology patients
    Bird, Paul W.
    Badhwar, Vinay
    Kennedy, Ben
    Ladani, Sapna
    Tang, Julian W. -T.
    JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (07) : 4585 - 4591
  • [42] Tracing the origin of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): A systematic review and narrative synthesis
    Thakur, Nagendra
    Das, Sayak
    Kumar, Swatantra
    Maurya, Vimal K.
    Dhama, Kuldeep
    Paweska, Janusz T.
    Abdel-Moneim, Ahmed S.
    Jain, Amita
    Tripathi, Anil K.
    Puri, Bipin
    Saxena, Shailendra K.
    JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (12) : 5766 - 5779
  • [43] Do Animals Play a Role in the Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)? A Commentary
    Costagliola, Anna
    Liguori, Giovanna
    d'Angelo, Danila
    Costa, Caterina
    Ciani, Francesca
    Giordano, Antonio
    ANIMALS, 2021, 11 (01):
  • [44] Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load Kinetics in Symptomatic Children, Adolescents, and Adults
    Bellon, Mathilde
    Baggio, Stephanie
    Bausch, Frederique Jacquerioz
    Spechbach, Herve
    Salamun, Julien
    Genecand, Camille
    Tardin, Aglae
    Kaiser, Laurent
    L'Huillier, Arnaud G.
    Eckerle, Isabella
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (06) : E1384 - E1386
  • [45] Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) - anatomic pathology perspective on current knowledge
    Mohanty, Sambit K.
    Satapathy, Abhishek
    Naidu, Machita M.
    Mukhopadhyay, Sanjay
    Sharma, Shivani
    Barton, Lisa M.
    Stroberg, Edana
    Duval, Eric J.
    Pradhan, Dinesh
    Tzankov, Alexandar
    Parwani, Anil, V
    DIAGNOSTIC PATHOLOGY, 2020, 15 (01)
  • [46] Immunobiology and nanotherapeutics of severe acute respiratory syndrome 2 (SARS-CoV-2): a current update
    Mba, Ifeanyi Elibe
    Sharndama, Hyelnaya Cletus
    Osondu-chuka, Goodness Ogechi
    Okeke, Onyekachi Philomena
    INFECTIOUS DISEASES, 2021, 53 (08) : 559 - 580
  • [47] Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in the Human Eye
    Kamalipour, Alireza
    Ashraf, Mohammad Ali
    Moghimi, Sasan
    Moattari, Afagh
    Ashraf, Mohammad Javad
    Abbasi, Farhad
    Azodi, Farzan
    Oboudi, Shadi
    Pirbonyeh, Neda
    Mokhtaryan, Maryam
    Roshanshad, Amirhossein
    Do, Jiun L.
    Weinreb, Robert N.
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2023, 31 (01) : 32 - 38
  • [48] Characteristics of Pleural Effusion in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pneumonia
    Chong, Woon H.
    Huggins, John Terrill
    Chopra, Amit
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2021, 361 (02): : 281 - 284
  • [49] The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Epidemic in Zimbabwe: Quo Vadis?
    Katsidzira, Leolin
    Gwaunza, Lenon
    Hakim, James G.
    CLINICAL INFECTIOUS DISEASES, 2020, 71 (16) : 2180 - 2183
  • [50] Emerging Biosensors to Detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Review
    Lim, Wei Yin
    Lan, Boon Leong
    Ramakrishnan, Narayanan
    BIOSENSORS-BASEL, 2021, 11 (11):