Emerging combination strategies with phototherapy in cancer nanomedicine

被引:553
作者
Xie, Zhongjian [1 ,2 ,3 ,4 ]
Fan, Taojian [1 ,2 ,3 ]
An, Jusung [5 ]
Choi, Wonseok [5 ]
Duo, Yanhong [1 ,2 ,3 ]
Ge, Yanqi [1 ,2 ,3 ]
Zhang, Bin [1 ,2 ,3 ]
Nie, Guohui [1 ,2 ,3 ]
Xie, Ni [1 ,2 ,3 ]
Zheng, Tingting [6 ]
Chen, Yun [6 ]
Zhang, Han [1 ,2 ,3 ]
Kim, Jong Seung [5 ]
机构
[1] Shenzhen Univ, Coll Phys & Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Peoples R China
[2] Shenzhen Univ, Otolaryngol Dept, Shenzhen 518060, Peoples R China
[3] Shenzhen Univ, Biobank Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
[4] Shenzhen Int Inst Biomed Res, Shenzhen 518116, Guangdong, Peoples R China
[5] Korea Univ, Dept Chem, Seoul 02841, South Korea
[6] Peking Univ, Shenzhen Hosp, Dept Ultrasound, Shenzhen Key Lab Drug Addict & Medicat Safety, Shenzhen 518036, Peoples R China
基金
新加坡国家研究基金会;
关键词
UP-CONVERSION NANOPARTICLES; NEAR-INFRARED-LIGHT; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; SEMICONDUCTING POLYMER; ANTITUMOR IMMUNITY; GRAPHENE OXIDE; GENE; OXYGEN; IMMUNOTHERAPY;
D O I
10.1039/d0cs00215a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics" becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.
引用
收藏
页码:8065 / 8087
页数:23
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