An in-silico analysis of the effect of heart position and orientation on the ECG morphology and vectorcardiogram parameters in patients with heart failure and intraventricular conduction defects

被引：34

作者：

Uyen Chau Nguyen ^{[1
]}

Potse, Mark ^{[2
]}

Regoli, Francois ^{[3
]}

Caputo, Maria Luce ^{[3
]}

Conte, Giulio ^{[3
]}

Murzilli, Romina ^{[3
]}

Muzzarelli, Stefano ^{[3
]}

Moccetti, Tiziano ^{[3
]}

Caiani, Enrico G. ^{[4
]}

Prinzen, Frits W. ^{[5
]}

Krause, Rolf ^{[2
]}

Auricchio, Angelo ^{[2
,3
]}

机构：

[1] Maastricht Univ, Fac Med, Maastricht, Netherlands

[2] Univ Svizzera Italiana, Inst Computat Sci, Ctr Computat Med Cardiol, CH-6904 Lugano, Switzerland

[3] Fdn Cardioctr Ticino, Div Cardiol, Lugano, Switzerland

[4] Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy

[5] Univ Limburg, Cardiovasc Res Inst Maastricht, Dept Physiol, NL-6200 MD Maastricht, Netherlands

来源：

JOURNAL OF ELECTROCARDIOLOGY | 2015年 / 48卷 / 04期

关键词：

Geometry; ECG morphology; VCG; Computer simulation; CARDIAC RESYNCHRONIZATION THERAPY; BUNDLE-BRANCH-BLOCK; LEFT-VENTRICULAR HYPERTROPHY; QRS-T ANGLE; INTERINDIVIDUAL VARIABILITY; ELECTROCARDIOGRAM; RECORDINGS; CARDIOLOGY; SOCIETY; MAPS;

D O I：

10.1016/j.jelectrocard.2015.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The aim of this study was to investigate the influence of geometrical factors on the ECG morphology and vectorcardiogram (VCG) parameters. Methods: Patient-tailored models based on five heart-failure patients with intraventricular conduction defects (IVCDs) were created. The heart was shifted up to 6 cm to the left, right, up, and down and rotated +/- 30 degrees around the anteroposterior axis. Precordial electrodes were shifted 3 cm down. Results: Geometry modifications strongly altered ECG notching/slurring and intrinsicoid deflection time. Maximum VCG parameter changes were small for QRS duration (-6% to +10%) and QRS-T angle (-6% to +3%), but considerable for QRS amplitude (-36% to +59%), QRS area (-37% to +42%), T-wave amplitude (-41% to +36%), and T-wave area (-42% to +33%). Conclusion: The position of the heart with respect to the electrodes is an important factor determining notching/slurring and voltage-dependent parameters and therefore must be considered for accurate diagnosis of IVCDs. (C) Elsevier Inc. All rights reserved.

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收藏

页码：617 / 625

页数：9

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