Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging

被引：405

作者：

Zhao, Zhenghuan ^{[1
,2
]}

Zhou, Zijian ^{[1
,2
]}

Bao, Jianfeng ^{[3
]}

Wang, Zhenyu ^{[3
]}

Hu, Juan ^{[1
,2
]}

Chi, Xiaoqin ^{[4
]}

Ni, Kaiyuan ^{[1
,2
]}

Wang, Ruifang ^{[3
]}

Chen, Xiaoyuan ^{[5
]}

Chen, Zhong ^{[3
]}

Gao, Jinhao ^{[1
,2
,6
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Fujian Key Lab Plasma & Magnet Resonance, Dept Phys & Elect Sci, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Zhongshan Hosp, Fujian Prov Key Lab Chron Liver Dis & Hepatocellu, Xiamen 361004, Peoples R China

[5] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

[6] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

基金：

中国国家自然科学基金;

关键词：

HIGH-INDEX FACETS; PLATINUM NANOCRYSTALS; PROSTATE-CANCER; MRI; PARTICLES; SIZE;

D O I：

10.1038/ncomms3266

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spherical superparamagnetic iron oxide nanoparticles have been developed as T-2-negative contrast agents for magnetic resonance imaging in clinical use because of their biocompatibility and ease of synthesis; however, they exhibit relatively low transverse relaxivity. Here we report a new strategy to achieve high transverse relaxivity by controlling the morphology of iron oxide nanoparticles. We successfully fabricate size-controllable octapod iron oxide nanoparticles by introducing chloride anions. The octapod iron oxide nanoparticles (edge length of 30 nm) exhibit an ultrahigh transverse relaxivity value (679.3 +/- 30 mM(-1)s(-1)), indicating that these octapod iron oxide nanoparticles are much more effective T-2 contrast agents for in vivo imaging and small tumour detection in comparison with conventional iron oxide nanoparticles, which holds great promise for highly sensitive, early stage and accurate detection of cancer in the clinic.

引用

页数：7

共 42 条

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