Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy

被引：55

作者：

Song, De-Gang ^{[1
]}

Powell, Daniel J., Jr. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

CD27; T cell; chimeric; antigen; receptor; lentivirus; cancer; costimulation; survival; memory; GENERATION;

D O I：

10.4161/onci.19458

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact of CD27 costimulation on human T lymphocyte effector function and memory formation has been limited to evaluations using in vitro cell culture systems and observations from the clinic. We therefore investigated whether CD27 signaling augments antigen redirected human T-cell survival, expansion and function in vitro and in vivo.

引用

页数：3

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