Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

被引：9

作者：

Gao, Zhiqiang ^{[1
]}

Shen, Wei ^{[1
]}

Deng, Huimin ^{[1
]}

Ren, Yuqian ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 04期

关键词：

POLYANILINE; NANOWIRES; LIGATION;

D O I：

10.1039/c2cc37450a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electrochemical biosensor utilizing the electron-transfer impeding (insulating) power of a conducting polymer for label-free genotyping single-nucleotide polymorphisms is proposed. Excellent selectivity and sensitivity are accomplished through the engagement of a nuclease clean-up step and a cumulative signal generation/amplification process, respectively.

引用

页码：370 / 372

页数：3

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