Convenient Synthesis of Novel Chalcone and Pyrazoline Sulfonamide Derivatives as Potential Antibacterial Agents

被引：33

作者：

Bonakdar, A. P. S. ^{[1
]}

Sadeghi, A. ^{[1
]}

Aghaei, H. R. ^{[1
]}

Beheshtimaal, K. ^{[2
]}

Nazifi, S. M. R. ^{[3
]}

Massah, A. R. ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Shahreza Branch, Shahreza 86145311, Iran

[2] Islamic Azad Univ, Dept Microbiol, Falavarjan Branch, Esfahan, Iran

[3] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Med Chem, Esfahan 8174673461, Iran

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2020年 / 46卷 / 03期

关键词：

chalcone; pyrazoline; sulfonamide; solvent-free; antibacterial activity; SOLVENT-FREE; ANTICANCER; EFFICIENT; INHIBITORS; CATALYST; DESIGN; ARYL;

D O I：

10.1134/S1068162020030048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel chalcone sulfonamide derivatives were synthesized starting from benzophenones and aldehydes in 3 steps. Also, (E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one was converted to different pyrazoline in four steps. The synthesis of sulfonamides was carried out under solvent-free conditions at room temperature and the products were obtained in high purity after a simple work-up without using any chromatography method for purification. All of the products were evaluated for their in vitro antibacterial activity againstStaphylococcus aureusandEscherichia coli.

引用

页码：371 / 381

页数：11

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