Desired Vancomycin Trough Serum Concentration for Treating Invasive Methicillin-resistant Staphylococcal Infections

被引：103
|
作者：
Frymoyer, Adam [1 ]
Guglielmo, B. Joseph [2 ]
Hersh, Adam L. [3 ]
机构：
[1] Stanford Univ, Dept Pediat, Palo Alto, CA 94304 USA
[2] Univ Calif San Francisco, Dept Clin Pharm, San Francisco, CA 94143 USA
[3] Univ Utah, Dept Pediat, Salt Lake City, UT USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 10期
关键词：
vancomycin; children; pharmacokinetics; methicillin-resistant Staphylococcus aureus; PEDIATRIC-PATIENTS; AUREUS INFECTIONS; DISEASES SOCIETY; CHILDREN; PHARMACODYNAMICS; PHARMACOKINETICS; NEPHROTOXICITY; GUIDELINES; AMERICA;
D O I：
10.1097/INF.0b013e318299f75c
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 g/mL. A trough of 7-10 g/mL predicted achievement of AUC/MIC >400 in >90% of children.
引用
收藏
页码：1077 / 1079
页数：3
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