Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase

被引：29

作者：

Burkhart, JP ^{[1
]}

Weintraub, PM ^{[1
]}

Gates, CA ^{[1
]}

Resvick, RJ ^{[1
]}

Vaz, RJ ^{[1
]}

Friedrich, D ^{[1
]}

Angelastro, MR ^{[1
]}

Bey, P ^{[1
]}

Peet, NP ^{[1
]}

机构：

[1] Aventis Pharmaceut, Bridgewater, NJ 08807 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(01)00354-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

20-Fluoro-17(20)-prognenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C-17(20) lyase. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：929 / 934

页数：6

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