Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

被引：17
|
作者：
Wang, Chao [1 ]
Shi, Min [1 ]
Ji, Jun [2 ]
Cai, Qu [1 ]
Zhao, Qianfu [1 ]
Jiang, Jinling [1 ]
Liu, Jing [1 ]
Zhang, Huan [3 ]
Zhu, Zhenggang [1 ,2 ]
Zhang, Jun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Oncol, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai Inst Digest Surg, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiol, Shanghai 200025, Peoples R China
来源：
AGING-US | 2020年 / 12卷 / 15期
基金：
美国国家科学基金会;
关键词：
SCD1; gastric cancer; ferroptosis; lipid metabolism; proliferation; GENE-EXPRESSION; METABOLISM; STEMNESS;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cancer cells are characterized by metabolic alterations. Thereinto, Stearoyl-CoA Desaturase 1 (SCD1), an enzymatic node located in the conversion of saturated fatty acids into monounsaturated fatty acids (MUFAs), has been reported to accelerate the tumorigenesis of multiple cancers. However, its role in the metabolic process of gastric cancer remains largely unexplored. In this study, by in vitro, in vivo and in silico assessments, our results revealed that SCD1 exhibited the ability to promote tumor growth, migration and anti-ferroptosis of gastric cancer. The underlying mechanism might involve the alteration of cancer stemness and modulation of cell cycle-related proteins. Moreover, based on our findings, high expression of SCD1 might predict poor prognosis in gastric cancer patients. Our study provided new insights into the potential of SCD1 as a biomarker as well as a therapeutic target in the treatment of gastric cancer.
引用
收藏
页码：15374 / 15391
页数：18
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