Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

被引：17
|
作者：
Wang, Chao [1 ]
Shi, Min [1 ]
Ji, Jun [2 ]
Cai, Qu [1 ]
Zhao, Qianfu [1 ]
Jiang, Jinling [1 ]
Liu, Jing [1 ]
Zhang, Huan [3 ]
Zhu, Zhenggang [1 ,2 ]
Zhang, Jun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Oncol, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai Inst Digest Surg, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiol, Shanghai 200025, Peoples R China
来源：
AGING-US | 2020年 / 12卷 / 15期
基金：
美国国家科学基金会;
关键词：
SCD1; gastric cancer; ferroptosis; lipid metabolism; proliferation; GENE-EXPRESSION; METABOLISM; STEMNESS;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cancer cells are characterized by metabolic alterations. Thereinto, Stearoyl-CoA Desaturase 1 (SCD1), an enzymatic node located in the conversion of saturated fatty acids into monounsaturated fatty acids (MUFAs), has been reported to accelerate the tumorigenesis of multiple cancers. However, its role in the metabolic process of gastric cancer remains largely unexplored. In this study, by in vitro, in vivo and in silico assessments, our results revealed that SCD1 exhibited the ability to promote tumor growth, migration and anti-ferroptosis of gastric cancer. The underlying mechanism might involve the alteration of cancer stemness and modulation of cell cycle-related proteins. Moreover, based on our findings, high expression of SCD1 might predict poor prognosis in gastric cancer patients. Our study provided new insights into the potential of SCD1 as a biomarker as well as a therapeutic target in the treatment of gastric cancer.
引用
收藏
页码：15374 / 15391
页数：18
相关论文
共 50 条
  • [31] Stearoyl CoA Desaturase 1 (SCD1) Is Upregulated in Rapidly Growing Myeloma Cells and Is Required for Cell Proliferation
    Venkateshaiah, Sathisha Upparahalli
    Khan, Sharmin
    Ling, Wen
    Saint John, Linda
    Bam, Rakesh
    Li, Xin
    Yaccoby, Shmuel
    BLOOD, 2011, 118 (21) : 1685 - 1686
  • [32] Stearoyl-CoA desaturase 1 as a therapeutic target for cancer: a focus on hepatocellular carcinoma
    Mortaza Raeisi
    Leila Hassanbeigi
    Fatemeh Khalili
    Hengameh Kharrati-Shishavan
    Mehdi Yousefi
    Amir Mehdizadeh
    Molecular Biology Reports, 2022, 49 : 8871 - 8882
  • [33] Milk fatty acid unsaturation:: Genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA:diacylglycerol acyltransferase 1 (DGAT1)
    Schennink, A.
    Heck, J. M. L.
    Bovenhuis, H.
    Visker, M. H. P. W.
    van Valenberg, H. J. F.
    van Arendonk, J. A. M.
    JOURNAL OF DAIRY SCIENCE, 2008, 91 (05) : 2135 - 2143
  • [34] Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody
    Katoh, Yuki
    Yaguchi, Tomonori
    Kubo, Akiko
    Iwata, Takashi
    Morii, Kenji
    Kato, Daiki
    Ohta, Shigeki
    Satomi, Ryosuke
    Yamamoto, Yasuhiro
    Oyamada, Yoshitaka
    Ouchi, Kota
    Takahashi, Shin
    Ishioka, Chikashi
    Matoba, Ryo
    Suematsu, Makoto
    Kawakami, Yutaka
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (07)
  • [35] Inhibition of Stearoyl-Coa desaturase 1 (SCD1) enzymatic activity reverts BRAFi and MEKi-induced selection of cancer stem cells in BRAF-mutated malignant melanoma
    Pisanu, Maria Elena
    Noto, Alessia
    Fattore, Luigi
    Malpicci, Debora
    Ciliberto, Gennaro
    Mancini, Rita
    JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
  • [36] Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death
    Tesfay, Lia
    Paul, Bibbin T.
    Konstorum, Anna
    Deng, Zhiyong
    Cox, Anderson O.
    Lee, Jingyun
    Furdui, Cristina M.
    Hegde, Poornima
    Torti, Frank M.
    Torti, Suzy V.
    CANCER RESEARCH, 2019, 79 (20) : 5355 - 5366
  • [37] Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer sternness via stabilization and nuclear localization of YAPfTAZ
    Noto, Alessia
    Pisanu, Maria Elena
    De Vitis, Claudia
    Sorrentino, Giovanni
    Del Sal, Giannino
    Budillon, Alfredo
    Ciliberto, Gennaro
    Mancini, Rita
    CANCER RESEARCH, 2016, 76
  • [38] Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells
    A Noto
    S Raffa
    C De Vitis
    G Roscilli
    D Malpicci
    P Coluccia
    A Di Napoli
    A Ricci
    M R Giovagnoli
    L Aurisicchio
    M R Torrisi
    G Ciliberto
    R Mancini
    Cell Death & Disease, 2013, 4 : e947 - e947
  • [39] Stearoyl-CoA desaturase 1 as a therapeutic target for cancer: a focus on hepatocellular carcinoma
    Raeisi, Mortaza
    Hassanbeigi, Leila
    Khalili, Fatemeh
    Kharrati-Shishavan, Hengameh
    Yousefi, Mehdi
    Mehdizadeh, Amir
    MOLECULAR BIOLOGY REPORTS, 2022, 49 (09) : 8871 - 8882
  • [40] Investigation of (Stearoyl-CoA Desaturase 1) SCD1 Gene Polymorphism in Khuzestan Buffalo Population Using PCR-RFLP Method
    Taghizadeh, K.
    Nasiri, M. T. Beigi
    Fayazi, J.
    Bujarpoor, M.
    IRANIAN JOURNAL OF APPLIED ANIMAL SCIENCE, 2014, 4 (02): : 425 - 428
12345