Telomeric DNA-RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells

被引：34

作者：

Bao, Hong-Liang ^{[1
]}

Xu, Yan ^{[1
]}

机构：

[1] Univ Miyazaki, Fac Med, Dept Med Sci, Div Chem, 5200 Kihara, Kiyotake, Miyazaki 8891692, Japan

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 48期

基金：

日本学术振兴会;

关键词：

STRUCTURES IN-VITRO; F-19; NMR; SEQUENCE FORMS; LIVING CELLS; TRANSCRIPTION; PARALLEL; MODELS;

D O I：

10.1039/d0cc02053b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, we employed a(19)F NMR approach to study the association of telomere RNA and DNAin vitroand in living human cells. We successfully characterized the DNA-RNA hybrid G-quadruplex (HQ) structure formed by telomeric DNA and RNA. We further demonstrated for the first time that an HQ conformation can exist in the environmental conditions of HeLa cells.

引用

页码：6547 / 6550

页数：4

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