Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis

被引：24
|
作者：
Yu, Wen-Jun [1 ]
Huang, Dong-Xu [1 ]
Liu, Shuang [2 ]
Sha, Ying-Li [3 ]
Gao, Feng-hui [4 ]
Liu, Hong [5 ]
机构：
[1] First Hosp Jilin Univ, Dept Hand & Foot Surg, Eastern Div, Changchun, Peoples R China
[2] First Hosp Jilin Univ, Dept Nursing Management, Eastern Div, Changchun, Peoples R China
[3] First Hosp Jilin Univ, Dept Pediat, Eastern Div, Changchun, Peoples R China
[4] First Hosp Jilin Univ, Dept Orthopaed, Eastern Div, Changchun, Peoples R China
[5] First Hosp Jilin Univ, Dept Otolaryngol, Eastern Div, Changchun, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2020年 / 10卷
关键词：
methotrexate; cancer; liposomes; LPHNPs; NLCs; NANOSTRUCTURED LIPID CARRIERS; IN-VIVO PHARMACOKINETICS; HYBRID NANOPARTICLES; BREAST-CANCER; TARGETED DELIVERY; CONTROLLED-RELEASE; SYSTEMS; MICELLES; NANOCARRIERS; PLATFORM;
D O I：
10.3389/fonc.2020.01734
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. The optimal dose of MTX is known to inhibit the dihydrofolatereductase that hinders the replication of purines. The nanobiomedicine has been extensively explored in the past decade to develop myriad functional nanostructures to facilitate the delivery of therapeutic agents for various medical applications. This review is focused on understanding the design and development of MTX-loaded nanoparticles alongside the inclusion of recent findings for the treatment of cancers. In this paper, we have made a coordinated effort to show the potential of novel drug delivery systems by achieving effective and target-specific delivery of methotrexate.
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页数：13
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