Mitosis: Cdh1 Clears the Way for Anaphase Spindle Assembly

被引：3

作者：

Gergely, Fanni ^{[1
]}

机构：

[1] Univ Cambridge, Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Dept Oncol, Cambridge CB2 0RE, England

来源：

CURRENT BIOLOGY | 2008年 / 18卷 / 21期

关键词：

D O I：

10.1016/j.cub.2008.08.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis.

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页码：R1009 / R1012

页数：4

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