Uveal melanomas are highly metastatic and have high rate of recurrence due to the lack of effective systemic therapy. The identification of important survival pathways in uveal melanomas provides novel therapeutic targets for effective treatment. In the present study, we found that the NF-kappa B signaling pathway was constitutively and highly activated in uveal melanoma cells. Treatment with the pharmacological NF-kappa B specific inhibitor BAY11-7082 markedly decreased the nuclear translocation of NF-kappa B. In a dose-dependent setting, BAY11-7082 inhibited the proliferation and growth of uveal melanoma cells by inducing apoptosis without effect on cell cycle. The migration capacity of uveal melanoma cells was also significantly suppressed by BAY11-7082 treatment. Mechanistically, BAY11-7082 increased the activity of caspase 3 and reduced the expression of anti-apoptotic protein Bcl-2, but did not influence the expression of pro-apoptotic protein Bax. Furthermore, BAY11-7082 induced uveal melanoma cell apoptosis and inhibited xenograft tumor growth in vivo. Collectively, the present study identified NF-kappa B as an important survival signal for uveal melanoma cells and suggested that administration of specific NF-kappa B inhibitor BAY11-7082 could serve as an effective treatment for patients with uveal melanoma.
机构:
Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Si, Lingling
Yan, Xinyan
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Peoples Hosp Xinjiang Uygur Autonomous Reg, Uygur 830001, Xinjiang, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Yan, Xinyan
Hao, Wenjin
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Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Hao, Wenjin
Ma, Xiaoyi
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机构:
Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Sch Pharm, Minist Educ, Shihezi 832002, Xinjiang, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Ma, Xiaoyi
Ren, Huanhuan
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机构:
Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Sch Pharm, Minist Educ, Shihezi 832002, Xinjiang, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Ren, Huanhuan
Ren, Boxue
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机构:
Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Sch Pharm, Minist Educ, Shihezi 832002, Xinjiang, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Ren, Boxue
Li, Defang
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机构:
Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Li, Defang
Dong, Zhengping
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Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
Dong, Zhengping
Zheng, Qiusheng
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Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R ChinaBinzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, 346 Guanhai Rd, Yantai 264000, Shandong, Peoples R China
机构:
Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
New York Eye & Ear Infirm Mt Sinai, Tissue Culture Ctr, New York, NY 10003 USAJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Bi, Ming-Chao
Hose, Nicole
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机构:
Fordham Univ, New York, NY 10023 USAJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Hose, Nicole
Xu, Cai-Lian
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机构:
Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R ChinaJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Xu, Cai-Lian
Zhang, Chen
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机构:
Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R ChinaJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Zhang, Chen
Sassoon, Jodi
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机构:
New York Eye & Ear Infirm Mt Sinai, Tissue Culture Ctr, New York, NY 10003 USAJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Sassoon, Jodi
Song, E.
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机构:
Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
Soochow Univ, Lixiang Eye Hosp, Suzhou 215021, Peoples R ChinaJilin Univ, Hosp 1, Dept Ophthalmol, Changchun 130021, Peoples R China
机构:
Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Zheng, Xi
Chang, Richard L.
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Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Chang, Richard L.
Cui, Xiao-Xing
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机构:
Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Cui, Xiao-Xing
Avila, Gina
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Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Avila, Gina
Huang, Mou-Tuan
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Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Huang, Mou-Tuan
Liu, Yue
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机构:Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Liu, Yue
Kong, Ah Ng Tony
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机构:
Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Kong, Ah Ng Tony
Rabson, Arnold B.
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机构:
Canc Inst New Jersey, New Brunswick, NJ 08903 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Rabson, Arnold B.
Conney, Allan H.
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机构:
Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
Canc Inst New Jersey, New Brunswick, NJ 08903 USARutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab, Piscataway, NJ 08854 USA
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Sun, Jiping
Xie, Liyi
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Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Xie, Liyi
Lv, Jing
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Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Lv, Jing
Zhang, Wenjing
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Zhang, Wenjing
Lv, Jia
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Lv, Jia
Liang, Yu
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Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Liang, Yu
Geng, Yingzhou
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
Geng, Yingzhou
Li, Xudong
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Urol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Nephrol, Xian, Shaanxi, Peoples R China
机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Tao, Jiali
Zhao, Hongmei
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机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Zhao, Hongmei
Xie, Xiaochen
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机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Resp, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Xie, Xiaochen
Luo, Man
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机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Luo, Man
Gao, Zhiwei
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机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Gao, Zhiwei
Sun, Hong
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机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China
Sun, Hong
Huang, Ziming
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency Surg, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, 1 Yellow River West Rd, Huaian 223300, Jiangsu, Peoples R China