Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins

被引：5

作者：

Tache, Andreia ^{[1
,2
]}

Radu, Gabriel-Lucian ^{[1
,2
]}

Litescu, Simona-Carmen ^{[1
]}

机构：

[1] Natl Inst Res & Dev Biol Sci, Bucharest 060031, Romania

[2] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Bucharest 0101061, Romania

来源：

CHEMICAL PAPERS | 2012年 / 66卷 / 12期

关键词：

lipoproteins; peroxyl radicals; hydroxyl radicals; copper ion; antioxidant; LIPID OXIDATION; ANTIOXIDANTS; POLYPHENOLS; PROOXIDANT; BIOSENSOR; MARKER; FOOD; GAS;

D O I：

10.2478/s11696-012-0233-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals' concentration over a range of 10(-6)-10(-5) mol L-1. Cu2+ accentuates lipoperoxidation but, when rosmarinic acid was present, Cu2+ produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu2+ and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1.

引用

页码：1166 / 1170

页数：5

共 26 条

[1] When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid [J].

Bagnati, M ;

Perugini, C ;

Cau, C ;

Bordone, R ;

Albano, E ;

Bellomo, G .

BIOCHEMICAL JOURNAL, 1999, 340 :143-152

[2] Sources of natural phenolic antioxidants [J].

Dimitrios, Boskou .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2006, 17 (09) :505-512

[3] Highly sensitive voltammetric biosensor for nitric oxide based on its high affinity with hemoglobin [J].

Fan, CH ;

Liu, XJ ;

Pang, JT ;

Li, GX ;

Scheer, H .

ANALYTICA CHIMICA ACTA, 2004, 523 (02) :225-228

[4] Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin [J].

Firth, Carole A. ;

Crone, Elizabeth M. ;

Flavall, Elizabeth A. ;

Roake, Ajustin A. ;

Gieseg, Steven P. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (06) :1095-1101

[5]

GUTTERIDGE JMC, 1995, CLIN CHEM, V41, P1819

[6]

Halliwell B., 2007, FREE RADICAL BIO MED, P502

[7] The wanderings of a free radical [J].

Halliwell, Barry .

FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (05) :531-542

[8] Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats [J].

Khaki, Arash ;

Imani, S. A. M. ;

Golzar, Farhad S. .

AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 6 (04) :248-252

[9] ANALYTICAL TECHNOLOGIES FOR LIPID OXIDATION-PRODUCTS ANALYSIS [J].

KINTER, M .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1995, 671 (1-2) :223-236

[10] Extracts of plant cell cultures of Lavandula vera and Rosa damascena as sources of phenolic antioxidants for use in foods [J].

Kovatcheva-Apostolova, Elena G. ;

Georgiev, Milen I. ;

Ilieva, Mladenka P. ;

Skibsted, Leif H. ;

Rodtjer, Anja ;

Andersen, Mogens Larsen .

EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2008, 227 (04) :1243-1249

← 1 2 3 →