Transcription factor PROX1: its role in development and cancer

被引：119
作者：
Elsir, Tamador [1 ,2 ]
Smits, Anja [2 ]
Lindstrom, Mikael S. [1 ]
Nister, Monica [1 ]
机构：
[1] Karolinska Inst, Dept Oncol Pathol, Karolinska Univ Hosp, S-17176 Stockholm, Sweden
[2] Uppsala Univ, Univ Uppsala Hosp, Dept Neurosci, S-75185 Uppsala, Sweden
来源：
CANCER AND METASTASIS REVIEWS | 2012年 / 31卷 / 3-4期
基金：
瑞典研究理事会;
关键词：
PROX1; Transcription factor; Cancer; Embryonic development; Glioma; ADULT HIPPOCAMPAL NEUROGENESIS; HOMEOBOX PROTEIN PROX1; SELF-RENEWAL; ASYMMETRIC SEGREGATION; LYMPHATIC ENDOTHELIUM; MOLECULAR-MECHANISMS; HOMEODOMAIN PROTEIN; STEM-CELLS; GENE PROX1; PROSPERO;
D O I：
10.1007/s10555-012-9390-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The homeobox gene PROX1 is critical for organ development during embryogenesis. The Drosophila homologue, known as prospero has been shown to act as a tumor suppressor by controlling asymmetric cell division of neuroblasts. Likewise, alterations in PROX1 expression and function are associated with a number of human cancers including hematological malignancies, carcinomas of the pancreas, liver and the biliary system, sporadic breast cancer, Kaposiform hemangioendothelioma, colon cancer, and brain tumors. PROX1 is involved in cancer development and progression and has been ascribed both tumor suppressive and oncogenic properties in a variety of different cancer types. However, the exact mechanisms through which PROX1 regulates proliferation, migration, and invasion of cancer cells are by large unknown. This review provides an update on the role of PROX1 in organ development and on its emerging functions in cancer, with special emphasis on the central nervous system and glial brain tumors.
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收藏
页码：793 / 805
页数：13
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