Linkage disequilibrium and association mapping

被引：68

作者：

Weir, B. S. ^{[1
]}

机构：

[1] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2008年 / 9卷

关键词：

case-control; gene-gene correlation; Hardy-Weinberg; three-locus disequilibrium; trend test;

D O I：

10.1146/annurev.genom.9.081307.164347

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Linkage disequilibrium refers to the association between alleles at different loci. The standard definition applies to two alleles in the same gamete, and it can be regarded as the covariance of indicator variables for the states of those two alleles. The corresponding correlation coefficient rho is the parameter that arises naturally in discussions of tests of association between markers and genetic diseases. A general treatment of association tests makes use of the additive and nonadditive components of variance for the disease gene. In almost all expressions that describe the behavior of association tests, additive variance components are modified by the squared correlation coefficient rho(2) and the nonadditive variance components by rho(4), suggesting that nonadditive components have less influence than additive components on association tests.

引用

页码：129 / 142

页数：14

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