Channel gate! Tension, leak and disclosure

被引：36

作者：

Batiza, AF

Rayment, I

Kung, C ^{[1
]}

机构：

[1] Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

STRUCTURE | 1999年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0969-2126(99)80061-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of a bacterial MscL shows how this homopentameric channel protein is held tightly shut to prevent leakage whilst at rest. By inference, the structure also shows how a stretch force in the lipid bilayer causes the channel to open. We now have a concrete picture as to how a stimulus 'gates' an ion channel.

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收藏

页码：R99 / R103

页数：5

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