Channel gate! Tension, leak and disclosure

被引：36

作者：

Batiza, AF

Rayment, I

Kung, C ^{[1
]}

机构：

[1] Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

STRUCTURE | 1999年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0969-2126(99)80061-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of a bacterial MscL shows how this homopentameric channel protein is held tightly shut to prevent leakage whilst at rest. By inference, the structure also shows how a stretch force in the lipid bilayer causes the channel to open. We now have a concrete picture as to how a stimulus 'gates' an ion channel.

引用

页码：R99 / R103

页数：5

共 28 条

[1] Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells
Ajouz, B
Berrier, C
Garrigues, A
Besnard, M
Ghazi, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) : 26670 - 26674
[2] Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E-coli
Arkin, IT
Sukharev, SI
Blount, P
Kung, C
Brünger, AT
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1998, 1369 (01): : 131 - 140
[3] Batiza AF, 1999, BIOPHYS J, V76, pA138
[4] A PATCH-CLAMP STUDY OF ION CHANNELS OF INNER AND OUTER MEMBRANES AND OF CONTACT ZONES OF ESCHERICHIA-COLI, FUSED INTO GIANT LIPOSOMES - PRESSURE-ACTIVATED CHANNELS ARE LOCALIZED IN THE INNER MEMBRANE
BERRIER, C
COULOMBE, A
HOUSSIN, C
GHAZI, A
[J]. FEBS LETTERS, 1989, 259 (01) : 27 - 32
[5] Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli
Blount, P
Sukharev, SI
Schroeder, MJ
Nagle, SK
Kung, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) : 11652 - 11657
[6] Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli
Blount, P
Sukharev, SI
Moe, PC
Schroeder, MJ
Guy, HR
Kung, C
[J]. EMBO JOURNAL, 1996, 15 (18) : 4798 - 4805
[7] Structure of the MscL homolog from Mycobacterium tuberculosis:: A gated mechanosensitive ion channel
Chang, G
Spencer, RH
Lee, AT
Barclay, MT
Rees, DC
[J]. SCIENCE, 1998, 282 (5397) : 2220 - 2226
[8] Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
Cruickshank, CC
Minchin, RF
LeDain, AC
Martinac, B
[J]. BIOPHYSICAL JOURNAL, 1997, 73 (04) : 1925 - 1931
[9] CUI C, 1995, J MEMBRANE BIOL, V144, P31
[10] MODIFIED RECONSTITUTION METHOD USED IN PATCH-CLAMP STUDIES OF ESCHERICHIA-COLI ION CHANNELS
DELCOUR, AH
MARTINAC, B
ADLER, J
KUNG, C
[J]. BIOPHYSICAL JOURNAL, 1989, 56 (03) : 631 - 636

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