Microsatellite mutations in the offspring of irradiated parents 19 years after the Cesium-137 accident

被引：21

作者：

da Cruz, Aparecido Divino ^{[1
,2
]}

de Melo e Silva, Daniela ^{[1
,2
]}

da Silva, Claudio Carlos ^{[1
,2
]}

Nelson, R. John ^{[1
,3
]}

Ribeiro, Ligia Maria ^{[2
]}

Pedrosa, Eduardo Rocha ^{[1
]}

Jayme, Jivago Carneiro ^{[1
]}

Curado, Maria Paula ^{[2
]}

机构：

[1] Univ Catolica Goias, Dept Biol Nucl Pesquisas Replicon, BR-74605010 Goiania, Go, Brazil

[2] Secretaria Estadual Saude Goias, Superintendencia Leide Neves Ferreira, Lab Citogenet Humana & Genet Mol LaGene, BR-74075150 Goiania, Go, Brazil

[3] Univ Victoria, Dept Biol, Victoria, BC V8P 5C2, Canada

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2008年 / 652卷 / 02期

关键词：

Cesium-137; Goias state; mutation rate; germline mutations;

D O I：

10.1016/j.mrgentox.2008.02.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In September of 1987, a radiotherapy unit containing 50.9 TBq of (CsCl)-Cl-137 was removed from an abandoned radiotherapy clinic. This unit was subsequently disassembled leading to the most serious radiological accident yet to occur in the Western hemisphere. This event provides an opportunity to assess the genetic effects of ionizing radiation. We surveyed genetic variation of 12 microsatellite loci in 10 families of exposed individuals and their offspring and also in non-exposed families from the same area of Goias state. We found an increase in the number of new alleles in the offspring of the exposed individuals. The mutation rate was found to be higher in the exposed families compared to the control group. These results indicated that exposure to ionizing radiation can be detected in offspring of exposed individuals and also suggest that the elevated microsatellite mutation rate can be attributed to radioactive exposure. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：175 / 179

页数：5

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