Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

被引：53

作者：

Fousteri, Georgia ^{[1
]}

Liossis, Stamatis-Nick C. ^{[2
]}

Battaglia, Manuela ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Diabet Res Inst, I-20132 Milan, Italy

[2] Univ Patras, Sch Med, Dept Rheumatol, Patras 26500, Greece

来源：

CLINICAL IMMUNOLOGY | 2013年 / 149卷 / 03期

关键词：

PTPN22; Autoimmunity; Genetic predisposition; Immune tolerance; T regulatory cells (Treg); Autoreactive cells; SYSTEMIC-LUPUS-ERYTHEMATOSUS; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS; SUSCEPTIBILITY GENE; R620W POLYMORPHISM; NK CELLS; VARIANT; ASSOCIATION; ALLELE; INTERFERON;

D O I：

10.1016/j.clim.2013.10.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in PTPN22 are associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type 1 diabetes. This review discusses the role of PTPN22 in T and B cells, and its function in innate immune cells, such as monocytes, dendritic cells and NK cells. We focus particularly on the complexity that underlies the function of PTPN22 in the biological processes of the immune system; such complexity has led various research groups to produce rather conflicting data. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：556 / 565

页数：10

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