Two new steroids with cytotoxicity from the marine sponge Dactylospongia elegans collected from the South China Sea

被引：15

作者：

Li, Jing ^{[2
]}

Wang, Zhuo ^{[2
]}

Yang, Fan ^{[2
]}

Jiao, Wei-Hua ^{[2
]}

Lin, Hou-Wen ^{[2
]}

Xu, Shi-Hai ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangzhou, Guangdong, Peoples R China

[2] Shanghai Jiao Tong Univ, Ren Ji Hosp, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs,Dept Pharm,Sch Med, Shanghai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 09期

关键词：

Marine sponge; Dactylospongia elegans; steroids; cytotoxicity; X-ray crystal analysis;

D O I：

10.1080/14786419.2018.1475385

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5 alpha,8 alpha-epidioxy-cholest-6-en-3 beta-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 mu M, respectively. [GRAPHICS] .

引用

页码：1340 / 1344

页数：5

共 11 条

[1] Marine natural products [J].

Blunt, John W. ;

Copp, Brent R. ;

Hu, Wan-Ping ;

Munro, Murray H. G. ;

Northcote, Peter T. ;

Prinsep, Michele R. .

NATURAL PRODUCT REPORTS, 2007, 24 (01) :31-86

[2]

Cutignano A, 2001, EUR J ORG CHEM, V2001, P775

[3] 5α,8α-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity [J].

Ioannou, Efstathia ;

Abdel-Razik, Ayman F. ;

Zervou, Maria ;

Christofidis, Dimitrios ;

Alexi, Xanthippi ;

Vagias, Constantinos ;

Alexis, Michael N. ;

Roussis, Vassilios .

STEROIDS, 2009, 74 (01) :73-80

[4] METABOLITES OF THE PALAUAN SPONGE DACTYLOSPONGIA SP [J].

KUSHLAN, DM ;

FAULKNER, DJ ;

PARKANYI, L ;

CLARDY, J .

TETRAHEDRON, 1989, 45 (11) :3307-3312

[5] SESTERTERPENE LACTONES FROM A SPONGE SPECIES OF THE GENUS DACTYLOSPONGIA [J].

LAL, AR ;

CAMBIE, RC ;

RICKARD, CEF ;

BERGQUIST, PR .

TETRAHEDRON LETTERS, 1994, 35 (16) :2603-2606

[6] Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper [J].

Li, Jing ;

Gu, Bin-Bin ;

Sun, Fan ;

Xu, Jian-Rong ;

Jiao, Wei-Hua ;

Yu, Hao-Bing ;

Han, Bing-Nan ;

Yang, Fan ;

Zhang, Xi-Chun ;

Lin, Hou-Wen .

JOURNAL OF NATURAL PRODUCTS, 2017, 80 (05) :1436-1445

[7] DACTYLTRONIC ACIDS FROM THE SPONGE DACTYLOSPONGIA ELEGANS [J].

LOPEZ, MD ;

QUINOA, E ;

RIGUERA, R ;

OMAR, S .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (07) :992-996

[8] THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA-ELEGANS [J].

RODRIGUEZ, J ;

QUINOA, E ;

RIGUERA, R ;

PETERS, BM ;

ABRELL, LM ;

CREWS, P .

TETRAHEDRON, 1992, 48 (32) :6667-6680

[9] Recent advances in deep-sea natural products [J].

Skropeta, Danielle ;

Wei, Liangqian .

NATURAL PRODUCT REPORTS, 2014, 31 (08) :999-1025

[10] A Phenylacetylated Peptide, JBIR-96, Isolated from Streptomyces sp RI051-SDHV6 [J].

Ueda, Jun-ya ;

Izumikawa, Miho ;

Kozone, Ikuko ;

Yamamura, Hideki ;

Hayakawa, Masayuki ;

Takagi, Motoki ;

Shin-ya, Kazuo .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (05) :1344-1347

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