The blood-brain barrier in brain homeostasis and neurological diseases

被引：551

作者：

Weiss, Nicolas ^{[1
]}

Miller, Florence ^{[1
]}

Cazaubon, Sylvie ^{[1
]}

Couraud, Pierre-Olivier ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, CNRS, UMR 8104,Inst Cochin,U567, F-75014 Paris, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 04期

关键词：

Blood-brain barrier; Tight-junction; Neurological disease; Drug delivery; Brain endothelium; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; INTERCELLULAR-ADHESION MOLECULE-1; MICROVASCULAR ENDOTHELIAL-CELLS; CEREBRAL-ARTERY OCCLUSION; NEURAL PRECURSOR CELLS; MATRIX METALLOPROTEINASES CONTRIBUTE; PLASMINOGEN-ACTIVATOR CROSSES; HUMAN GLIOBLASTOMA-MULTIFORME;

D O I：

10.1016/j.bbamem.2008.10.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally. They form the blood-brain-barrier (BBB) which strictly controls the exchanges between the blood and the brain compartments by limiting passive diffusion of blood-borne solutes while actively transporting nutrients to the brain. Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases with important social impacts, such as multiple sclerosis, stroke, brain tumors, epilepsy or Alzheimer's disease. This review will focus on the implication of brain endothelial tight junctions in BBB architecture and physiology, will discuss the consequences of BBB dysfunction in these CNS diseases and will present some therapeutic strategies for drug delivery to the brain across the BBB. (C) 2008 Elsevier B.V. All rights reserved

引用

页码：842 / 857

页数：16

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