SYSTEMIC IRON HOMEOSTASIS

被引:859
作者
Ganz, Tomas [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Med, Los Angeles, CA 90095 USA
关键词
HEPCIDIN MESSENGER-RNA; YERSINIA-ENTEROCOLITICA INFECTION; ANTIMICROBIAL PEPTIDE HEPCIDIN; PROTEASE MATRIPTASE-2 TMPRSS6; DIFFERENTIATION FACTOR 15; RED-BLOOD-CELLS; REGULATES HEPCIDIN; MOUSE MODEL; HEREDITARY HEMOCHROMATOSIS; DEFICIENCY ANEMIA;
D O I
10.1152/physrev.00008.2013
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
引用
收藏
页码:1721 / 1741
页数:21
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