The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland

被引：81

作者：

Kondrashova, Anita ^{[1
]}

Seiskari, Tapio ^{[1
,2
]}

Ilonen, Jorma ^{[3
,4
]}

Knip, Mikael ^{[5
,6
,7
,8
]}

Hyoty, Heikki ^{[1
,2
]}

机构：

[1] Univ Tampere, Dept Virol, Tampere 33520, Finland

[2] Fimlab Labs, Dept Clin Microbiol, Tampere, Finland

[3] Univ Eastern Finland, Dept Clin Microbiol, Kuopio, Finland

[4] Univ Turku, Immunogenet Lab, Turku, Finland

[5] Univ Helsinki, Childrens Hosp, Helsinki, Finland

[6] Univ Helsinki, Cent Hosp, Helsinki, Finland

[7] Folkhalsan Res Ctr, Helsinki, Finland

[8] Tampere Univ Hosp, Dept Pediat, Tampere, Finland

来源：

APMIS | 2013年 / 121卷 / 06期

基金：

芬兰科学院;

关键词：

Hygiene hypothesis; infections; autoimmune diseases; allergy; Finland; Russian Karelia; REGULATORY T-CELLS; DEPENDENT DIABETES-MELLITUS; HAY-FEVER; EARLY-CHILDHOOD; ENTEROVIRUS INFECTIONS; ENVIRONMENTAL-FACTORS; ATOPIC-DERMATITIS; IMMUNE-RESPONSE; YOUNG-CHILDREN; LOW-PREVALENCE;

D O I：

10.1111/apm.12023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune and allergic diseases have become a major health problem in the Western world during past decades. The hygiene hypothesis suggests that decreased microbial exposure in childhood leads to increasing prevalence of these diseases. This review summarizes epidemiological evidence and current immunological knowledge concerning the hygiene hypothesis. Recent results from Russian Karelia and Finland imply that environmental factors have greatly contributed to the increasing prevalence of immune-mediated disorders. Infections, or lack of them, may indeed be strongly involved in the development of both autoimmune and allergic diseases.

引用

页码：478 / 493

页数：16

共 119 条

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