Intracellular Pathogen Detection by RIG-I-Like Receptors

被引：135

作者：

Dixit, Evelyn

Kagan, Jonathan C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 117 | 2013年 / 117卷

关键词：

NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSES; TOLL-LIKE RECEPTOR-3; E3 UBIQUITIN LIGASE; DOUBLE-STRANDED-RNA; IFN-BETA PROMOTER; ENDOPLASMIC-RETICULUM; ADAPTER PROTEIN; 5'-TRIPHOSPHATE RNA;

D O I：

10.1016/B978-0-12-410524-9.00004-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatoty cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.

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页码：99 / 125

页数：27

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