Intracellular Pathogen Detection by RIG-I-Like Receptors

被引：131
作者：
Dixit, Evelyn
Kagan, Jonathan C. [1 ]
机构：
[1] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
ADVANCES IN IMMUNOLOGY, VOL 117 | 2013年 / 117卷
关键词：
NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSES; TOLL-LIKE RECEPTOR-3; E3 UBIQUITIN LIGASE; DOUBLE-STRANDED-RNA; IFN-BETA PROMOTER; ENDOPLASMIC-RETICULUM; ADAPTER PROTEIN; 5'-TRIPHOSPHATE RNA;
D O I：
10.1016/B978-0-12-410524-9.00004-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatoty cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.
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收藏
页码：99 / 125
页数：27
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共 109 条
  • [1] RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    Ablasser, Andrea
    Bauernfeind, Franz
    Hartmann, Gunther
    Latz, Eicke
    Fitzgerald, Katherine A.
    Hornung, Veit
    [J]. NATURE IMMUNOLOGY, 2009, 10 (10) : 1065 - U40
  • [2] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
    Arimoto, Kei-ichiro
    Takahashi, Hitoshi
    Hishiki, Takayuki
    Konishi, Hicleyuki
    Fujita, Takashi
    Shimotohno, Kunitada
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) : 7500 - 7505
  • [3] An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
    Arnoult, Damien
    Soares, Fraser
    Tattoli, Ivan
    Castanier, Celine
    Philpott, Dana J.
    Girardin, Stephen E.
    [J]. JOURNAL OF CELL SCIENCE, 2009, 122 (17) : 3161 - 3168
  • [4] Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes
    Auerbuch, V
    Brockstedt, DG
    Meyer-Morse, N
    O'Riordan, M
    Portnoy, DA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) : 527 - 533
  • [5] Nucleic Acid Recognition by the Innate Immune System
    Barbalat, Roman
    Ewald, Sarah E.
    Mouchess, Maria L.
    Barton, Gregory M.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 : 185 - 214
  • [6] A cell biological view of Toll-like receptor function: regulation through compartmentalization
    Barton, Gregory M.
    Kagan, Jonathan C.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2009, 9 (08) : 535 - 542
  • [7] Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing
    Baum, Alina
    Sachidanandam, Ravi
    Garcia-Sastre, Adolfo
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (37) : 16303 - 16308
  • [8] An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    Buerckstuemmer, Tilmann
    Baumann, Christoph
    Blueml, Stephan
    Dixit, Evelyn
    Duernberger, Gerhard
    Jahn, Hannah
    Planyavsky, Melanie
    Bilban, Martin
    Colinge, Jacques
    Bennett, Keiryn L.
    Superti-Furga, Giulio
    [J]. NATURE IMMUNOLOGY, 2009, 10 (03) : 266 - 272
  • [9] Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to listeria infection
    Carrero, JA
    Calderon, B
    Unanue, ER
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) : 535 - 540
  • [10] TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA
    Charrel-Dennis, Marie
    Latz, Eicke
    Halmen, Kristen A.
    Trieu-Cuot, Patrick
    Fitzgerald, Katherine A.
    Kasper, Dennis L.
    Golenbock, Douglas T.
    [J]. CELL HOST & MICROBE, 2008, 4 (06) : 543 - 554
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