Intracellular Pathogen Detection by RIG-I-Like Receptors

被引：135
作者：
Dixit, Evelyn
Kagan, Jonathan C. [1 ]
机构：
[1] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
ADVANCES IN IMMUNOLOGY, VOL 117 | 2013年 / 117卷
关键词：
NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSES; TOLL-LIKE RECEPTOR-3; E3 UBIQUITIN LIGASE; DOUBLE-STRANDED-RNA; IFN-BETA PROMOTER; ENDOPLASMIC-RETICULUM; ADAPTER PROTEIN; 5'-TRIPHOSPHATE RNA;
D O I：
10.1016/B978-0-12-410524-9.00004-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatoty cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.
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页码：99 / 125
页数：27
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