BRCA1 AND TOP2A GENE AMPLIFICATION AND PROTEIN EXPRESSION IN FOUR MOLECULAR SUBTYPES OF BREAST CANCER

被引：1

作者：

Mitrovic, Olivera ^{[1
]}

Micic, Mileva ^{[1
]}

Cokic, V. ^{[1
]}

Koko, Vesna ^{[2
]}

Dikic, Dragoslava ^{[1
]}

Budec, Mirela ^{[1
]}

Vignjevic, Sanja ^{[1
]}

Brekovic, Tijana ^{[1
]}

机构：

[1] Univ Belgrade, Inst Med Res, Belgrade 11000, Serbia

[2] Univ Belgrade, Fac Biol, Belgrade 11000, Serbia

来源：

ARCHIVES OF BIOLOGICAL SCIENCES | 2013年 / 65卷 / 02期

关键词：

BRCA1; TOP2A; FISH; immunohistochemistry; molecular subtypes of breast cancer; TOPOISOMERASE-II-ALPHA; OVEREXPRESSION; CHEMOTHERAPY; HER-2/NEU; DELETION;

D O I：

10.2298/ABS1302511M

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients.

引用

页码：511 / 518

页数：8

共 14 条

[1] Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines
Arriola, Edurne
Marchio, Caterina
Tan, David Sp
Drury, Suzanne C.
Lambros, Maryou B.
Natrajan, Rachael
Rodriguez-Pinilla, Socorro Maria
Mackay, Alan
Tamber, Narinder
Fenwick, Kerry
Jones, Chris
Dowsett, Mitch
Ashworth, Alan
Reis-Filho, Jorge S.
[J]. LABORATORY INVESTIGATION, 2008, 88 (05) : 491 - 503
[2] Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer
Bertolo, Cristina
Guerrero, David
Vicente, Francisco
Cordoba, Alicia
Esteller, Manel
Ropero, Santiago
Guillen-Grima, Francisco
Maria Martinez-Penuela, Jose
Miguel Lera, Jose
[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 130 (03) : 414 - 424
[3] HER-2/neu and topoisomerase IIα gene amplification and protein expression in invasive breast carcinomas -: Chromogenic in situ hybridization and immunohistochemical analyses
Bhargava, R
Lal, P
Chen, BY
[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2005, 123 (06) : 889 - 895
[4] ERBB2 and TOP2A in Breast Cancer: A Comprehensive Analysis of Gene Amplification, RNA Levels, and Protein Expression and Their Influence on Prognosis and Prediction
Brase, Jan C.
Schmidt, Marcus
Fischbach, Thomas
Sueltmann, Holger
Bojar, Hans
Koelbl, Heinz
Hellwig, Birte
Rahnenfuehrer, Joerg
Hengstler, Jan G.
Gehrmann, Mathias C.
[J]. CLINICAL CANCER RESEARCH, 2010, 16 (08) : 2391 - 2401
[5] Cardoso F, 2004, INT J ONCOL, V24, P201
[6] Coon JS, 2002, CLIN CANCER RES, V8, P1061
[7] HER-2/neu and topoisomerase IIα in breast cancer
Järvinen, TAH
Liu, ET
[J]. BREAST CANCER RESEARCH AND TREATMENT, 2003, 78 (03) : 299 - 311
[8] Järvinen TAH, 1999, GENE CHROMOSOME CANC, V26, P142
[9] Marchio C., 2008, Diagnostic Histopathology, V14, P202, DOI DOI 10.1016/J.MPDHP.2008.03.002
[10] Topoisomerase IIalpha-positive and BRCA1-negative phenotype: Association with favorable response to epirubicin-based regimens for human breast cancers
Miyoshi, Yasuo
Kurosumi, Masafumi
Kurebayashi, Junichi
Matsuura, Nariaki
Takahashi, Masato
Tokunaga, Eriko
Egawa, Chiyomi
Masuda, Norikazu
Kim, Seung Jin
Okishiro, Masatsugu
Yanagisawa, Tetsu
Ueda, Satsuki
Taguchi, Tetsuya
Tamaki, Yasuhiro
Noguchi, Shinzaburo
[J]. CANCER LETTERS, 2008, 264 (01) : 44 - 53

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