The 5-Ws of immunotherapy in head and neck cancer

被引：14

作者：

Botticelli, Andrea ^{[1
]}

Mezi, Silvia ^{[2
]}

Pomati, Giulia ^{[2
]}

Cerbelli, Bruna ^{[2
]}

Di Rocco, Christiana ^{[3
]}

Amirhassankhani, Sasan ^{[4
]}

Sirgiovanni, Grazia ^{[2
]}

Occhipinti, Mario ^{[2
]}

Napoli, Valerio ^{[2
]}

Emiliani, Alessandra ^{[2
]}

Mazzuca, Federica ^{[1
]}

Tomao, Silverio ^{[2
]}

Nuti, Marianna ^{[5
]}

Marchetti, Paolo ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Clin & Mol Med, Viale Regina Elena 326, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Radiol Oncol & Pathol Sci Dept, Policlin Umberto I, Viale Regina Elena 326, I-00161 Rome, Italy

[3] IDI IRCCS, Ist Dermopat Immacolata, Via Monti Creta 104, I-00167 Rome, Italy

[4] Guys & St Thomas NHS Fdn Trust, Westminster Bridge Rd, London SE1 7EH, England

[5] Sapienza Univ Rome, Fac Med & Dent, Dept Expt Med, Viale Regina Elena 326, I-00161 Rome, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 153卷

关键词：

Immunotherapy; Immune checkpoint inhibitors; PD-1/PD-L1; axis; Immunosuppressive microenvironment; Head and neck cancer; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; TUMOR-INFILTRATING LYMPHOCYTES; ANTIGEN-PROCESSING MACHINERY; HPV-ASSOCIATED HEAD; INDUCTION CHEMOTHERAPY; PD-1; BLOCKADE; LUNG-CANCER; T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE;

D O I：

10.1016/j.critrevonc.2020.103041

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Recent clinical trials showed that only a small subset of patients really benefits from immunotherapy. This review aims to highlight the five W-points of immunotherapy: why immunotherapy is promising in HNSCC, what is currently available in daily clinical practice, when immunotherapy can be integrated into the therapeutic strategy, where it can be useful according to predictive response biomarker, who, among patients, could get the best benefit from immunotherapy and how improve the achieved results.

引用

页数：16

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