Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population

被引：23
|
作者：
Mohapatra, Sudhesna [1 ]
Saxena, Alpana [1 ]
Gandhi, Gauri [2 ]
Koner, Bidhan Chandra [1 ]
Ray, Prakash Chandra [1 ]
机构：
[1] Maulana Azad Med Coll, Dept Biochem, Delhi 110002, India
[2] Maulana Azad Med Coll, Dept Obstet & Gynecol, Delhi 110002, India
来源：
JOURNAL OF OVARIAN RESEARCH | 2013年 / 6卷
关键词：
D-RECEPTOR POLYMORPHISMS; BONE-MINERAL DENSITY; MORTALITY-RATES; COLON; RISK; SUNLIGHT; LIGAND; US;
D O I：
10.1186/1757-2215-6-37
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Introduction: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined. Objective: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer. Material and methods: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay. Results: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype. Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4). Conclusion: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.
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页数：6
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