Apolipoprotein E and Measured Physical and Pulmonary Function in Older Taiwanese Adults

被引:16
作者
Vasunilashorn, Sarinnapha [1 ]
Glei, Dana A. [2 ]
Lin, Yu-Hsuan
Goldman, Noreen [1 ]
机构
[1] Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA
[2] Georgetown Univ, Ctr Populat & Hlth, Washington, DC USA
关键词
E GENOTYPE; CARDIOVASCULAR-DISEASE; AFRICAN-AMERICAN; FOLLOW-UP; MORTALITY; ASSOCIATION; POLYMORPHISM; POPULATION; MOBILITY; RISK;
D O I
10.1080/19485565.2013.778703
中图分类号
C921 [人口统计学];
学科分类号
摘要
The apolipoprotein E (ApoE) gene, which has three common alleles (E2, E3, and E4), has been linked to a number of health outcomes and longevity. The E2 allele has been reported to have neuroprotective effects, whereas the E4 allele has been shown to be a risk factor for cardiovascular disease and Alzheimer's disease in various populations. The relationships between ApoE and mortality and ApoE and physical function, however, are not clear-cut. We used the Social Environment and Biomarkers of Aging Study (SEBAS) to examine the relationship between ApoE polymorphisms and physical and pulmonary function in approximately 1,000 Taiwanese adults aged 53 years and older in 2006. In the 2006 SEBAS wave, measures of physical function included self-reported difficulties with respect to activities of daily living (ADLs) and other physical function indicators, as well as performance-based measures of grip strength (kg), walking speed (m/s) over a distance of 3 m, and chair stand speed (stand/s). Peak expiratory flow (PEF; L/min) rate was also examined as an indicator of pulmonary function. We used logistic regression models to determine the association between ApoE and inability to complete each of the tests of physical and pulmonary function. These models revealed no significant association between ApoE carrier status and any of the indicators of function. Among participants able to complete a given task, we next used linear regression models to examine self-reported limitations with ADLs and performance on the given test by ApoE carrier status. Similarly, there were no significant relationships between ApoE carrier status and the measures of function. Our estimates provide further confirmation that the ApoE gene may not be a risk factor for functional decline among older Taiwanese adults.
引用
收藏
页码:57 / 67
页数:11
相关论文
共 34 条
[1]   APOE genotype influences functional status among elderly without dementia [J].
Albert, SM ;
Gurland, B ;
Maestre, G ;
Jacobs, DM ;
Stern, Y ;
Mayeux, R .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (06) :583-587
[2]   The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults [J].
Blazer, DG ;
Fillenbaum, G ;
Burchett, B .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (12) :M785-M789
[3]  
Chang M., 2007, BIOSOCIAL SURVEYS CO, P60
[4]   Lower levels of physical functioning are associated with higher body weight among middle-aged and older women [J].
Coakley, EH ;
Kawachi, I ;
Manson, JE ;
Speizer, FE ;
Willet, WC ;
Colditz, GA .
INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (10) :958-965
[5]   INTERRELATIONSHIPS OF PEAK EXPIRATORY FLOW-RATE WITH PHYSICAL AND COGNITIVE FUNCTION IN THE ELDERLY - MACARTHUR FOUNDATION STUDIES OF AGING [J].
COOK, NR ;
ALBERT, MS ;
BERKMAN, LF ;
BLAZER, D ;
TAYLOR, JO ;
HENNEKENS, CH .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 (06) :M317-M323
[6]   PEAK EXPIRATORY FLOW-RATE AND 5-YEAR MORTALITY IN AN ELDERLY POPULATION [J].
COOK, NR ;
EVANS, DA ;
SCHERR, PA ;
SPEIZER, FE ;
TAYLOR, JO ;
HENNEKENS, CH .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1991, 133 (08) :784-794
[7]   GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].
CORDER, EH ;
SAUNDERS, AM ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
SCIENCE, 1993, 261 (5123) :921-923
[8]   Demographic and Socioeconomic Status Differences in Perceptions of Difficulty With Mobility in Late Life [J].
Cornman, Jennifer C. ;
Glei, Dana ;
Rodriguez, German ;
Goldman, Noreen ;
Hurng, Baai-Shyun ;
Weinstein, Maxine .
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES, 2011, 66 (02) :237-248
[9]   FACTORS INFLUENCING PUBLICATION OF RESEARCH RESULTS - FOLLOW-UP OF APPLICATIONS SUBMITTED TO 2 INSTITUTIONAL REVIEW BOARDS [J].
DICKERSIN, K ;
MIN, YI ;
MEINERT, CL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (03) :374-378
[10]   PUBLICATION BIAS IN CLINICAL RESEARCH [J].
EASTERBROOK, PJ ;
BERLIN, JA ;
GOPALAN, R ;
MATTHEWS, DR .
LANCET, 1991, 337 (8746) :867-872