Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery

被引：35
|
作者：
Huang, Jia-Lin [1 ,2 ]
Chen, Hong-Zhuan [1 ]
Gao, Xiao-Ling [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Fac Basic Med, Dept Pharmacol & Chem Biol, Sch Med, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Renji Hosp, Dept Neurol Surg, Sch Med, Shanghai, Peoples R China
来源：
JOURNAL OF DRUG TARGETING | 2018年 / 26卷 / 5-6期
基金：
中国国家自然科学基金;
关键词：
Liposome; calcium phosphate; lipid-coated calcium-phosphate nanoparticles; endosomal escape; reconstituted high-density lipoprotein; drug delivery; CANCER-THERAPY; HYBRID NANOPARTICLES; TARGETED DELIVERY; SYSTEMIC DELIVERY; SIRNA DELIVERY; CO-DELIVERY; LIPOSOMES; TUMOR; CISPLATIN; DNA;
D O I：
10.1080/1061186X.2017.1419360
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make LCP become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers. Here, we briefly review the history of the development of LCP NPs, highlight the optimisations and modulations in the development process, and summarise the major applications of LCP NPs and LCP-derived NPs in drug delivery.
引用
收藏
页码：398 / 406
页数：9
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